Helios defines T cells being driven to tolerance in the periphery and thymus
Ellen M Ross, Dorothee Bourges, Thea V Hogan, Paul A Gleeson, Ian R van Driel
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2014
The expression of the Ikaros transcription factor family member, Helios, has been shown to be associated with T-cell tolerance in both the thymus and the periphery. To better understand the importance of Helios in tolerance pathways, we have examined the expression of Helios in TCR-transgenic T cells specific for the gastric H(+) /K(+) ATPase, the autoantigen target in autoimmune gastritis. Analysis of H(+) /K(+) ATPase-specific T cells in mice with different patterns of H(+) /K(+) ATPase expression revealed that, in addition to the expression of Helios in CD4(+) Foxp3(+) regulatory T (Treg) cells, Helios is expressed by a large proportion of CD4(+) Foxp3(-) T cells in both the thymus and th..View full abstract
We thank Maxwell Walker and staff at the Bio21 animal facility. This work was supported by research awards from the National Health and Medical Research Council of Australia and the University of Melbourne. E. R. was a recipient of an Australian Postgraduate Award from the Commonwealth Government of Australia.