Journal article
SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling
D Anthony, JL McQualter, M Bishara, EX Lim, S Yatmaz, HJ Seow, M Hansen, M Thompson, JA Hamilton, LB Irving, BD Levy, R Vlahos, GP Anderson, S Bozinovski
FASEB Journal | FEDERATION AMER SOC EXP BIOL | Published : 2014
DOI: 10.1096/fj.14-250332
Abstract
Serum amyloid A (SAA) is expressed locally in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), where macrophages that do not accord with the classic M1/M2 paradigm also accumulate. In this study, the role of SAA in regulating macrophage differentiation was investigated in vitro using human blood monocytes from healthy subjects and patients with COPD and in vivo using an airway SAA challenge model in BALB/c mice. Differentiation of human monocytes with SAA stimulated the proinflammatory monokines IL-6 and IL-1β concurrently with the M2 markers CD163 and IL-10. Furthermore, SAA-differentiated macrophages stimulated with lipopolysaccharide (LPS) expressed ma..
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Awarded by National Institute of General Medical Sciences
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia.