Journal article

Fluidized Bed Layer-by-Layer Microcapsule Formation

Joseph J Richardson, Darwin Teng, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Jiwei Cui, George V Franks, Frank Caruso

LANGMUIR | AMER CHEMICAL SOC | Published : 2014

Abstract

Polymer microcapsules can be used as bioreactors and artificial cells; however, preparation methods for cell-like microcapsules are typically time-consuming, low yielding, and/or involve custom microfluidics. Here, we introduce a rapid (∼30 min per batch, eight layers), scalable (up to 500 mg of templates), and efficient (98% yield) microcapsule preparation technique utilizing a fluidized bed for the layer-by-layer (LbL) assembly of polymers, and we investigate the parameters that govern the formation of robust capsules. Fluidization in water was possible for particles of comparable diameter to mammalian cells (>5 μm), with the experimental flow rates necessary for fluidization matching well..

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