Fluidized Bed Layer-by-Layer Microcapsule Formation
Joseph J Richardson, Darwin Teng, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Jiwei Cui, George V Franks, Frank Caruso
LANGMUIR | AMER CHEMICAL SOC | Published : 2014
Polymer microcapsules can be used as bioreactors and artificial cells; however, preparation methods for cell-like microcapsules are typically time-consuming, low yielding, and/or involve custom microfluidics. Here, we introduce a rapid (∼30 min per batch, eight layers), scalable (up to 500 mg of templates), and efficient (98% yield) microcapsule preparation technique utilizing a fluidized bed for the layer-by-layer (LbL) assembly of polymers, and we investigate the parameters that govern the formation of robust capsules. Fluidization in water was possible for particles of comparable diameter to mammalian cells (>5 μm), with the experimental flow rates necessary for fluidization matching well..View full abstract
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Awarded by Australian Research Council
This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and the Super Science Fellowship (F.C., FS110200025) schemes, as well as the Australian Government through an Australian Postgraduate Award (M.B.) and an International Postgraduate Research Scholarship (M.B.).