Journal article

Characteristics of Fecal and Mucosa-Associated Microbiota in Chinese Patients With Inflammatory Bowel Disease

Liping Chen, Wei Wang, Rui Zhou, Siew C Ng, Jin Li, Meifang Huang, Feng Zhou, Xin Wang, Bo Shen, Michael A Kamm, Kaichun Wu, Bing Xia

Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

The intestinal microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD), and geographical and genetic backgrounds impact the composition of the intestinal microbiota. However, there is a lack of evidence regarding the overall changes and characteristics of fecal-associated microbiota (FAM) and mucosa-associated microbiota (MAM) in Chinese patients with IBD. We recruited 26 patients with Crohn's disease (CD), 46 patients with ulcerative colitis (UC), and 21 healthy individuals; we collected matched fresh fecal and mucosal samples from the same subjects. The microbial communities were studied by 454-pyrosequencing. Community-wide changes in FAM and MAM were ob..

View full abstract

Grants

Awarded by Hubei Science and Technology Bureau


Awarded by Wuhan University


Awarded by Ministry of Science and Technology of P. R. China


Funding Acknowledgements

This research was supported in part by the Hubei Science and Technology Bureau (under Grant 303,131,796), in part by Wuhan University (under Grant 117,030), and in part by the Ministry of Science and Technology of P. R. China (under Grant 2012BAI06B03).