Foxp3 expression in T regulatory cells and other cell lineages
Christel Devaud, Phillip K Darcy, Michael H Kershaw
CANCER IMMUNOLOGY IMMUNOTHERAPY | SPRINGER | Published : 2014
Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the forkhead/winged-helix family of transcriptional regulators. Foxp3 has been extensively studied over the past 13 years as a master regulator of transcription in a specific T-cell type, CD4(+) regulatory T cells (Treg), both in humans and in mice. Compelling data characterize Foxp3 as critically important and necessary for the development and the differentiation of Treg. It has been considered initially as the only specific marker for Treg. However, recent work has proposed that Foxp3 can be expressed by other types of lymphoid cells or myeloid cells and also by some non-hematopoietic cells such as epithelial cell..View full abstract
This work was supported by funding from the National Health and Medical Research Council of Australia and the Cancer Council of Victoria.