Journal article

Genome-wide association study success in ophthalmology

David A Mackey, Alex W Hewitt

Current Opinion in Ophthalmology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

PURPOSE OF REVIEW: Much progress in our understanding of the genetic profile of many ophthalmic diseases has been made over the last decade. Identification of novel gene associations allows insight into the mechanisms of disease and potentially enables the identification of individuals at increased risk, as well as facilitating the development of new treatments. We highlight key recent discoveries using the genome-wide association study design. RECENT FINDINGS: Over the last 2 years, we have seen major international collaborations successfully conduct genome-wide association study to identify genetic pathways associated with eye diseases, such as myopia, age-related macular degeneration and ..

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