Genome-wide association study success in ophthalmology
David A Mackey, Alex W Hewitt
Current Opinion in Ophthalmology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
PURPOSE OF REVIEW: Much progress in our understanding of the genetic profile of many ophthalmic diseases has been made over the last decade. Identification of novel gene associations allows insight into the mechanisms of disease and potentially enables the identification of individuals at increased risk, as well as facilitating the development of new treatments. We highlight key recent discoveries using the genome-wide association study design. RECENT FINDINGS: Over the last 2 years, we have seen major international collaborations successfully conduct genome-wide association study to identify genetic pathways associated with eye diseases, such as myopia, age-related macular degeneration and ..View full abstract
Funding: This work was supported by grants from National Health and Medical Research Council (NHMRC) and The Ophthalmic Research Institute of Australia (ORIA). The Centre for Eye Research Australia (CERA) receives operational infrastructure support from the Victorian government.