A practical guide to subtotal nephrectomy in the rat with subsequent methodology for assessing renal and cardiac function
Yuan Zhang, Andrew R Kompa
Nephrology | WILEY-BLACKWELL | Published : 2014
BACKGROUND: Chronic kidney disease (CKD), and its associated cardiovascular events, is one of the major causes of morbidity and recurrent hospitalization in Asian Pacific region. The subtotal nephrectomy (STNx) model has remained the state-of-the-art prototype which closely mimics human CKD and cardiac-renal syndrome. AIM AND METHODS: In this article, we comprehensively outline the procedure and methodology required to develop the rat model 5/6 nephrectomy and the associated procedures involved in assessing cardiac and renal functional outcomes. RESULTS AND CONCLUSION: In addition, the expected functional outcomes from our own experience, and those of others, have been described. The STNx mo..View full abstract
Awarded by NHMRC
The authors thank Professor Darren Kelly for his support and guidance in completion of this manuscript. The authors acknowledge the support from NHMRC program grant ID546272.