Macrophage depletion abates porphyromonas gingivalis-induced alveolar bone resorption in mice

Abstract

The role of the macrophage in the immunopathology of periodontitis has not been well defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis resulted in infection, alveolar bone resorption, and a significant increase in F4/80+macrophages in gingival and submandibular lymph node tissues. Macrophage depletion using clodronateliposomes resulted in a significant reduction in F4/80+macrophage infiltration of gingival and submandibular lymph node tissues and significantly (p < 0.01) less P. gingivalis-induced bone resorption compared with controls in BALB/c and C57BL/6 mice. In both mouse strains, the P. gingivalis-specific IgG Ab subclass and serum cytokin..