Intrahepatic Activation of Naive CD4( ) T Cells by Liver-Resident Phagocytic Cells
Szun S Tay, Yik Chun Wong, Ben Roediger, Frederic Sierro, Bo Lu, David M McDonald, Claire M McGuffog, Nicholas J Meyer, Ian E Alexander, Ian A Parish, William R Heath, Wolfgang Weninger, G Alex Bishop, Jennifer R Gamble, Geoffrey W McCaughan, Patrick Bertolino, David G Bowen
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2014
Naive T cell activation is normally restricted to the lymphoid organs, in part because of their limited ability to migrate into the parenchyma of peripheral tissues. The liver vasculature is unique, however, and circulating leukocytes within the hepatic sinusoids have direct access to liver-resident cells, which include an abundant population of Kupffer cells. It is well accepted that recognition of cognate Ag within the liver leads to naive CD8(+) T cell activation in situ, but it is unclear whether the liver also supports naive CD4(+) T cell activation. In this study, we show that naive CD4(+) T cells can be activated to proliferate in the liver when cognate Ag expression is induced in hep..View full abstract
Awarded by National Health and Medical Reasearch Council (NHMRC) Australia
Awarded by NHMRC
This work was supported by National Health and Medical Reasearch Council (NHMRC) Australia Program Grant 571408. P.B. was supported by NHMRC Senior Research Fellowship 511903. J.R.G. holds the University of Sydney Wenkart Chair of Endothelium Medicine at the Centenary Institute.