Journal article
Build better bones with exercise: Protocol for a feasibility study of a multicenter randomized controlled trial of 12 months of home exercise in women with a vertebral fracture
LM Giangregorio, L Thabane, JD Adachi, MC Ashe, RR Bleakney, EA Braun, AM Cheung, LA Fraser, JC Gibbs, KD Hill, AB Hodsman, DL Kendler, N Mittmann, S Prasad, SC Scherer, JD Wark, A Papaioannou
Physical Therapy | Published : 2014
DOI: 10.2522/ptj.20130625
Abstract
Background. Our goal is to conduct a multicenter randomized controlled trial (RCT) to investigate whether exercise can reduce incident fractures compared with no intervention among women aged ≥65 years with a vertebral fracture. Objectives. This pilot study will determine the feasibility of recruitment, retention, and adherence for the proposed trial. Design. The proposed RCT will be a pilot feasibility study with 1:1 randomization to exercise or attentional control groups. Setting. Five Canadian sites (1 community hospital partnered with an academic center and 4 academic hospitals or centers affiliated with an academic center) and 2 Australian centers (1 academic hospital and 1 center for c..
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Funding Acknowledgements
The Build Better Bones With Exercise (B3E) trial was funded by the Canadian Institutes of Health Research (CIHR) (http://www.cihr-irsc.gc.ca/e/193:html). This funding source had no role in the design of the study and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results. Dr Giangregorio is a CIHR New Investigator. She received funding from the CIHR Randomized Controlled Trials Mentoring Program to support activities related to the development of the protocol and an Early Researcher Award from the Ontario Ministry of Research and Innovation, as well as infrastructure funding from the Canadian Foundation for Innovation and the Ontario Research Fund. Dr Ashe is supported by career awards from the Michael Smith Foundation for Health Research and the CIHR.