Journal article
Changes over time in sex assignment for disorders of sex development
Z Kolesinska, SF Ahmed, M Niedziela, J Bryce, M Molinska-Glura, M Rodie, J Jiang, RO Sinnott, IA Hughes, F Darendeliler, O Hiort, Y Van Der Zwan, M Cools, T Guran, PM Holterhus, S Bertelloni, L Lisa, W Arlt, N Krone, M Ellaithi Show all
Pediatrics | Published : 2014
Abstract
BACKGROUND AND OBJECTIVE: It is unclear whether the proportion of infants with a disorder of sex development who are raised as male or female has changed over time. The temporal trends in sex assignment of affected cases entered in the International Disorder of Sex Development (I-DSD) Registry were studied.METHODS: Cases of disorders of sex development reported as partial androgen insensitivity syndrome (PAIS; n = 118), disorder of gonadal development (DGD; n = 232), and disorder of androgen synthesis (DAS; n = 104) were divided into those who were born before 1990, 1990-1999, and after 1999. External appearance of the genitalia was described by the external masculinization score.RESULTS: Th..
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Awarded by Medical Research Council
Funding Acknowledgements
This research was supported by the European Society for Paediatric Endocrinology Visiting Scholarship Scheme (Dr Kolesinska). The International Disorder of Sex Development (I-DSD) Registry is supported by a Medical Research Council partnership award G1100236 (Drs Ahmed, Bryce, Jiang, Rodie, and Sinnott) and was initially developed under a grant from the Seventh European Union Framework Program (grant 201444).