Journal article
Systematic regional variations in Purkinje cell spiking patterns
J Xiao, NL Cerminara, Y Kotsurovskyy, H Aoki, A Burroughs, AK Wise, Y Luo, SP Marshall, I Sugihara, R Apps, EJ Lang
Plos One | Published : 2014
Open access
Abstract
In contrast to the uniform anatomy of the cerebellar cortex, molecular and physiological studies indicate that significant differences exist between cortical regions, suggesting that the spiking activity of Purkinje cells (PCs) in different regions could also show distinct characteristics. To investigate this possibility we obtained extracellular recordings from PCs in different zebrin bands in crus IIa and vermis lobules VIII and IX in anesthetized rats in order to compare PC firing characteristics between zebrin positive (Z+) and negative (Z-) bands. In addition, we analyzed recordings from PCs in the A2 and C1 zones of several lobules in the posterior lobe, which largely contain Z+ and Z-..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
This work was supported by grants to EJL from the National Science Foundation, United States of America (www.NSF.gov) (Grant: IOS-1051858) and National Institute of Neurological Disorders and Stroke (www.ninds.nih.gov) (Grant: NS-37028), to RA and NLC from the Medical Research Council, United Kingdom (www.mrc.ac.uk/index.htm) (Grant: G1100626), and to IS from the Japan Society for the Promotion of Science (JSPS) (www.jsps.go.jp/english/) (Grants-in- Aid for Scientific Research-KAKENHI, 25430032). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.