Journal article
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, CQ Nie, M Kalanon, SC Charnaud, PR Sanders, SA Chisholm, NA Counihan, PJ Shaw, P Pino, JA Chan, MF Azevedo, SJ Rogerson, JG Beeson, BS Crabb, PR Gilson, TF De Koning-Ward
Nature | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/nature13555
Abstract
During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol1-6. These proteins have a variety of roles that are essential to virulence or parasite growth. There is keen interest in understanding how proteins are exported and whether common machineries are involved in trafficking the different classes of exported proteins8,9. One potential trafficking machine is a protein complex known as the Plasmodium translocon of exported proteins (PTEX) 10. Although PTEX has been linked to the export of one class of exported proteins10,11, there has been no direct evidence for its role..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
We thank T. Templeton, B. Franke-Fayard, C. Janse, A. Cowman, J. Boddey, B. Cooke, M. Duffy, L. Tilley, R. Anders, F. Fowkes, A. McLean and D. Bursac for reagents and/or other assistance with aspects of this study; D. Stanisic, F. Baiwog and I. Mueller for contributions to clinical studies of pregnant women; and P. Siba. We also thank the Australian Red Cross Blood Bank for the provision of human blood and serum. This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (1021560, 1025665 and 637406) and the Victorian State Government Operational Infrastructure Support Scheme. T.F.d.K.-W. is an NHMRC Career Development Fellow, and J.G.B. is a NHMRC Senior Research Fellow. B.E. and K.M. are the recipients of Australian Postgraduate Awards.