Potential Molecular and Cellular Mechanism of Psychotropic Drugs
Myoung Suk Seo, Elizabeth Scarr, Chi-Yu Lai, Brian Dean
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | Published : 2014
Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treat these disorders, they give sub-optimal recovery in many people and a significant number of individuals do not respond to any treatments and remain treatment resistant. Surprisingly, the mechanism by which psychotropic drugs cause their therapeutic benefits remain unknown but likely involves the underlying molecular pathways affected by the drugs. Hence, in this review, we have focused on recent findings on the molecular mechanism affected by antipsychotic, mood stabilizing and antidepressant drugs at the levels of epigenetics, intracellular signalling cascades and ..View full abstract
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Awarded by NHMRC project grant
Brian Dean is an NHMRC Senior Research Fellow (APP1002240) and Elizabeth Scan is an ARC Future Fellow (FT100100689). This work was supported in part by NHMRC project grants (APP628699) and (APP1045619), the Victorian Government's Operational Infrastructure Support and the Rebecca Cooper Medical Research Foundation. The authors declare no conflict of interest.