Journal article
Chromosome 12p13 variants predict recurrence of ischaemic stroke in a Chinese population
Z Zhang, G Xu, W Zhu, L Cao, W Bai, Y Xiong, B Yan, X Liu
European Journal of Neurology | WILEY | Published : 2014
DOI: 10.1111/ene.12508
Abstract
Background and purpose: A recent genome-wide association study identified two genetic variants (rs12425791 and rs11833579) on chromosome 12p13 that confer risk of ischaemic stroke. The purpose of this study was to examine whether these two polymorphisms are associated with stroke onset and prognosis in a Chinese population. Methods: rs12425791 and rs11833579 were genotyped using the improved multiple ligase detection reaction in 913 patients with ischaemic stroke. Analyses of genotype association with onset and prognosis outcomes were evaluated by the Kaplan-Meier method, the log-rank test and Cox proportional hazards models. Results: rs12425791 and rs11833579 were not associated with age of..
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Funding Acknowledgements
This work was supported by the National Natural Science Foundation of China (31200938, 81220108008); the Natural Science Foundation of Jiangsu Province (BK2011021); and the Natural Science Foundation of Jinling Hospital (2012009). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.