Journal article
Ovine IgA-reactive proteins from teladorsagia circumcincta infective larvae
S Ellis, JB Matthews, DJ Shaw, S Paterson, HEG McWilliam, NF Inglis, AJ Nisbet
International Journal for Parasitology | Published : 2014
Abstract
Infection of small ruminants with Teladorsagia circumcincta has, until now, been controlled using a combination of pasture management and frequent anthelmintic treatments. Resistance to the commonly used anthelmintics has driven research into the development of a subunit vaccine, encouraged by the demonstration of development of protective immunity in sheep following exposure to this parasite. Local immune effectors in the abomasum, in particular IgA, are thought to play important roles in naturally- and experimentally-acquired immunity. L3s represent the first contact of this pathogen with the host immune system and, herein, the presence of L3 antigen-specific IgA was demonstrated in abomas..
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Awarded by Rural and Environment Science and Analytical Services Division
Funding Acknowledgements
The authors gratefully acknowledge Dr W.D. Smith (Moredun Research Institute, UK) for kindly donating ovine mucus and lymph samples, and for the parasitological data. The authors also thank Moredun Research Institute parasitology laboratory members and Bioservices Division for technical and logistical support. We would like to thank Dr. Rachael Baker, formerly of Moredun Research Institute, for allowing us to use her electron microscopy image of Li T. circumcincta in our graphical abstract. SE was funded by the Moredun Innovation Fund and AJN and JBM receive financial support from the Scottish Government Rural and Environmental Science and Analytical Services division (RESAS), UK.