Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

BM Wolpin; C Rizzato; P Kraft; C Kooperberg; GM Petersen; Z Wang; AA Arslan; L Beane-Freeman; PM Bracci; J Buring; F Canzian; EJ Duell; S Gallinger; GG Giles; GE Goodman; PJ Goodman; EJ Jacobs; A Kamineni; AP Klein; LN Kolonel; MH Kulke; D Li; N Malats; SH Olson; HA Risch; HD Sesso; K Visvanathan; E White; W Zheng; CC Abnet; D Albanes; G Andreotti; MA Austin; R Barfield; D Basso; SI Berndt; MC Boutron-Ruault; M Brotzman; MW Büchler; HB Bueno-De-Mesquita; P Bugert; L Burdette; D Campa; NE Caporaso; G Capurso; C Chung; M Cotterchio; E Costello; J Elena; N Funel; JM Gaziano; NA Giese; EL Giovannucci; M Goggins; MJ Gorman; M Gross; CA Haiman; M Hassan; KJ Helzlsouer; BE Henderson; EA Holly; N Hu; DJ Hunter; F Innocenti; M Jenab; R Kaaks; TJ Key; KT Khaw; EA Klein; M Kogevinas; V Krogh; J Kupcinskas; RC Kurtz; A Lacroix; MT Landi; S Landi; L Le Marchand; A Mambrini; S Mannisto; RL Milne; Y Nakamura; AL Oberg; K Owzar; AV Patel; PHM Peeters; U Peters; R Pezzilli; A Piepoli; M Porta; FX Real; E Riboli; N Rothman; A Scarpa; XO Shu; DT Silverman; P Soucek; M Sund; R Talar-Wojnarowska; PR Taylor; GE Theodoropoulos

Journal article

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

BM Wolpin, C Rizzato, P Kraft, C Kooperberg, GM Petersen, Z Wang, AA Arslan, L Beane-Freeman, PM Bracci, J Buring, F Canzian, EJ Duell, S Gallinger, GG Giles, GE Goodman, PJ Goodman, EJ Jacobs, A Kamineni, AP Klein, LN Kolonel Show all

Nature Genetics | Published : 2014

DOI: 10.1038/ng.3052

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 ×..

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University of Melbourne Researchers

Prof Roger Milne Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This project was funded in whole or in part with federal funds from the National Cancer Institute (NCI), US National Institutes of Health (NIH) under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, and mention of trade names, commercial products or organizations does not imply endorsement by the US government. Major support for PanScan III sample identification and processing was provided by the Lustgarten Foundation for Pancreatic Cancer Research. Additional support was received from NIH/NCI K07 CA140790, the American Society of Clinical Oncology Conquer Cancer Foundation, the Howard Hughes Medical Institute, the Lustgarten Foundation, the Robert T. and Judith B. Hale Fund for Pancreatic Cancer Research and Promises for Purple to B.M.W. A full list of acknowledgments for each participating study is provided in the Supplementary Note.