Functional dysconnectivity of corticostriatal circuitry and differential response to methylphenidate in youth with attention-deficit/hyperactivity disorder
Soon-Beom Hong, Ben J Harrison, Alex Fornito, Chul-Ho Sohn, In-Chan Song, Jae-Won Kim
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | CMA-CANADIAN MEDICAL ASSOC | Published : 2015
BACKGROUND: Brain frontostriatal circuits have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). However, effects of methylphenidate on circuit-level functional connectivity are as yet unclear. The aim of the present study was to comprehensively investigate the functional connectivity of major striatal subregions in children with ADHD, including subanalyses directed at mapping cognitive and treatment response characteristics. METHODS: Using a comprehensive seeding strategy, we examined resting-state functional connectivity of dorsal and ventral subdivisions of the caudate nucleus and putamen in children and adolescents with ADHD and in age- and sex-ma..View full abstract
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Awarded by Basic Science Program through the National Research Foundation of Korea
Awarded by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Fellowship
This work was supported by the Basic Science Program through the National Research Foundation of Korea (2010-0002283 to J.-W. Kim). S.-B. Hong was supported by a National Research Foundation of Korea (NRF) grant (Global Internship Program) funded by the Korean government (MEST). B.J. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Fellowship (I.D. 628509). A. Fornito is supported by a Monash University Larkins Fellowship. The funding organizations had no influence on the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. S.-B. Hong had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.