Comprehensive molecular characterization of gastric adenocarcinoma

AJ Bass; V Thorsson; I Shmulevich; SM Reynolds; M Miller; B Bernard; T Hinoue; PW Laird; C Curtis; H Shen; DJ Weisenberger; N Schultz; R Shen; N Weinhold; DP Kelsen; R Bowlby; A Chu; K Kasaian; AJ Mungall; AG Robertson; P Sipahimalani; AD Cherniack; G Getz; Y Liu; MS Noble; C Pedamallu; C Sougnez; A Taylor-Weiner; R Akbani; JS Lee; W Liu; GB Mills; D Yang; W Zhang; A Pantazi; M Parfenov; M Gulley; MB Piazuelo; BG Schneider; J Kim; A Boussioutas; M Sheth; JA Demchok; CS Rabkin; JE Willis; S Ng; K Garman; DG Beer; A Pennathur; BJ Raphael; HT Wu; R Odze; HK Kim; J Bowen; KM Leraas; TM Lichtenberg; S Weaver; M McLellan; M Wiznerowicz; R Sakai; MS Lawrence; K Cibulskis; L Lichtenstein; S Fisher; SB Gabriel; ES Lander; L Ding; B Niu; A Ally; M Balasundaram; I Birol; D Brooks; YSN Butterfield; R Carlsen; J Chu; E Chuah; HJE Chun; A Clarke; N Dhalla; R Guin; RA Holt; SJM Jones; D Lee; HA Li; E Lim; Y Ma; MA Marra; M Mayo; RA Moore; KL Mungall; KM Nip; JE Schein; A Tam; N Thiessen; R Beroukhim; SL Carter; J Cho; D DiCara; S Frazer; N Gehlenborg

Journal article

Comprehensive molecular characterization of gastric adenocarcinoma

AJ Bass, V Thorsson, I Shmulevich, SM Reynolds, M Miller, B Bernard, T Hinoue, PW Laird, C Curtis, H Shen, DJ Weisenberger, N Schultz, R Shen, N Weinhold, DP Kelsen, R Bowlby, A Chu, K Kasaian, AJ Mungall, AG Robertson Show all

Nature | Published : 2014

DOI: 10.1038/nature13480

Open access

Download PDF

Abstract

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations o..

View full abstract

University of Melbourne Researchers

Michael Lawrence Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

We are grateful to all the patients and families who contributed to this study and to C. Gunter and J. Weinstein for scientific editing, to M. Sheth for administrative support and to L. Omberg for support with the Sage Bionetworks Synapse platform. This work was supported by the Intramural Research Program and the following grants from the United States National Institutes of Health: 5U24CA143799, 5U24CA143835, 5U24CA143840, 5U24CA143843, 5U24CA143845, 5U24CA143848, 5U24CA143858, 5U24CA143866, 5U24CA143867, 5U24CA143882, 5U24CA143883, 5U24CA144025, U54HG003067, U54HG003079, U54HG003273 and P30CA16672.