Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
Jeannine Diesch, Ross D Hannan, Elaine Sanij
CELL AND BIOSCIENCE | BMC | Published : 2014
Ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) drives cell growth and underlies nucleolar structure and function, indirectly coordinating many fundamental cellular processes. The importance of keeping rDNA transcription under tight control is reflected by the fact that deranged Pol I transcription is a feature of cancer and other human disorders. In this review, we discuss multiple aspects of rDNA function including the relationship between Pol I transcription and proliferative capacity, the role of Pol I transcription in mediating nucleolar structure and integrity, and rDNA/nucleolar interactions with the genome and their influence on heterochromatin and global g..View full abstract
We thank Dr. Austen Ganley (Massey University, New Zealand), Dr. Gretchen Poortinga (Peter MacCallum Cancer Centre, Australia) and Ms Jaclyn Quin (Peter MacCallum Cancer Centre, Australia) for critical evaluation of the manuscript. This work was supported by Grants from the National Health and Medical Research Council of Australia (NHMRC). RDH is supported by a NHMRC Fellowship.