Journal article
Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels
P Requena, JJ Campo, AJ Umbers, M Ome, R Wangnapi, D Barrios, LJ Robinson, P Samol, A Rosanas-Urgell, I Ubillos, A Mayor, M López, E De Lazzari, M Arévalo-Herrera, C Fernández-Becerra, H Del Portillo, CE Chitnis, PM Siba, A Bardají, I Mueller Show all
Journal of Immunology | Published : 2014
Abstract
Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered distribution of peripheral memory B cell (MBC) subsets. To study the combined impact of high malaria exposure and pregnancy in B cell subpopulations, we analyzed PBMCs from pregnant and nonpregnant individuals from a malaria-nonendemic country (Spain) and from a high malaria-endemic country (Papua New Guinea). In the malaria-naive cohorts, pregnancy was associated with a significant expansion of all switched (IgD-) MBC and a decrease of naive B cells. Malaria-exposed women had more atypical MBC ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The PREGVAX project was supported by European Union Seventh Framework Programme (FP7/2007-2013) Grant 201588 and Ministerio de Economia y Competitividad (National R&D Internationalisation Programme, EUROSALUD 2008, Spain) Grant EUS2009-03560. In addition, Papua New Guinea studies were supported by the Malaria in Pregnancy Consortium through Bill and Melinda Gates Foundation Grant 46099. C.D. was supported by a fellowship from the Ministerio de Economia y Competitividad (RYC-2008-02631); I.M. was supported by a National Health and Medical Research Council Senior Research Fellowship (GNT1043345); and L.J.R. was supported by a National Health and Medical Research Council Early Career Fellowship (1016443). C.D. and H.d.P. are affiliates and members of the European Union FP7 Network of Excellence EviMalaR.