Sleep disruption in tetraplegia: A randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin

Abstract

Study design:Randomised, double-blind, placebo-controlled crossover trial of melatonin supplementation to people with complete tetraplegia.Objectives:To investigate the effect that 3 mg melatonin supplementation has on objective and subjective sleep, quality of life and mood of people living with complete tetraplegia.Setting:Austin Hospital Sleep Laboratory and participants' homes, Melbourne, Victoria, Australia.Methods:Two week run-in followed by 3 week nightly administration of 3 mg melatonin or placebo, 2-week washout and further 3 week administration of the opposite treatment. Four testing sessions were conducted; the last nights of the run-in, treatment and washout periods. Testing sess..