A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

AA Al Olama; Z Kote-Jarai; SI Berndt; DV Conti; F Schumacher; Y Han; S Benlloch; DJ Hazelett; Z Wang; E Saunders; D Leongamornlert; S Lindstrom; S Jugurnauth-Little; T Dadaev; M Tymrakiewicz; DO Stram; K Rand; P Wan; A Stram; X Sheng; LC Pooler; K Park; L Xia; J Tyrer; LN Kolonel; L Le Marchand; RN Hoover; MJ Machiela; M Yeager; L Burdette; CC Chung; A Hutchinson; K Yu; C Goh; M Ahmed; K Govindasami; M Guy; TLJ Tammela; A Auvinen; T Wahlfors; J Schleutker; T Visakorpi; KA Leinonen; J Xu; M Aly; J Donovan; RC Travis; TJ Key; A Siddiq; F Canzian; KT Khaw; A Takahashi; M Kubo; P Pharoah; N Pashayan; M Weischer; BG Nordestgaard; SF Nielsen; P Klarskov; MA Røder; P Iversen; SN Thibodeau; SK McDonnell; DJ Schaid; JL Stanford; S Kolb; S Holt; B Knudsen; AH Coll; SM Gapstur; WR Diver; VL Stevens; C Maier; M Luedeke; K Herkommer; AE Rinckleb; SS Strom; C Pettaway; ED Yeboah; Y Tettey; RB Biritwum; AA Adjei; E Tay; A Truelove; S Niwa; AP Chokkalingam; L Cannon-Albright; C Cybulski; D Wokołorczyk; W Kluźniak; J Park; T Sellers; HY Lin; WB Isaacs; AW Partin; H Brenner; AK Dieffenbach; C Stegmaier; C Chen; EL Giovannucci

Journal article

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

AA Al Olama, Z Kote-Jarai, SI Berndt, DV Conti, F Schumacher, Y Han, S Benlloch, DJ Hazelett, Z Wang, E Saunders, D Leongamornlert, S Lindstrom, S Jugurnauth-Little, T Dadaev, M Tymrakiewicz, DO Stram, K Rand, P Wan, A Stram, X Sheng Show all

Nature Genetics | Published : 2014

DOI: 10.1038/ng.3094

Abstract

© 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10-8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was asso..

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