Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal; Grant Dewson; Marie Menard; Paul Frederick; Sweta Iyer; Ray Bartolo; Leonie Gibson; Peter E Czabotar; Brian J Smith; Jerry M Adams; Ruth M Kluck

Journal article

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E Czabotar, Brian J Smith, Jerry M Adams, Ruth M Kluck

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014

DOI: 10.1073/pnas.1415142111

University of Melbourne Researchers

Peter Czabotar Author Medical Biology (W.E.H.I.)

Sweta Iyer Author Medical Biology (W.E.H.I.)

Jerry Adams Author Medical Biology (W.E.H.I.)

Grant Dewson Author Medical Biology (W.E.H.I.)

Ruth Kluck Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Funding Acknowledgements

We thank T. Kratina for technical support; N. Church, J.-G. Zhang, R. Uren, C. Hockings, and M. Ritchie for advice on isoelectric focusing and statistics; P. Colman for comments on the manuscript; and T. Kitamura for the pMX-IG vector. This work was supported in part by a Deutsche Forschungsgemeinschaft postdoctoral fellowship (to D.W.), the National Health and Medical Research Council (575559 and 1016701), the Australian Research Council (FT100100754 and FT100100791), the Leukemia and Lymphoma Society, the Victorian State Government Operational Infrastructure Support, and the Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.