Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax
Brad E Sleebs, Michelle Gazdik, Matthew T O'Neill, Pravin Rajasekaran, Sash Lopaticki, Kurt Lackovic, Kym Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2014
Awarded by National Health and Medical Research Council of Australia
Awarded by Human Frontiers Science Program
Awarded by Ramaciotti Foundation
Awarded by CASS Foundation Science and Medicine
This work was funded by the National Health and Medical Research Council of Australia (project grant 1010326 to JAB.), the Human Frontiers Science Program (RGY0073/2012 to JAB.), the Ramaciotti Foundation (establishment grant 3197/2010 to JAB.), a CASS Foundation Science and Medicine grant (SM.12.4348 to JAB.), the Australian Cancer Research Foundation, and a Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. We thank the University of Melbourne for the provision of a postgraduate scholarship awarded to M.G. A.F.C. is a Howard Hughes International Scholar and an Australia Fellow of the NHMRC. JAB. is a QEII Fellow of the Australian Research Council. We thank Dr Guillaume Lessene and Prof. David Huang for their helpful discussions.