MCL and Mincle: C-type lectin receptors that sense damaged self and pathogen-associated molecular patterns
MB Richardson, SJ Williams
Frontiers in Immunology | Frontiers Research Foundation | Published : 2014
Macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage-associated and pathogen-associated molecular patterns. In this review, we cover the discovery and molecular characterization of these C-type lectin receptors, and highlight recent advances in the understanding of their roles in orchestrating the response of the immune system to bacterial and fungal infection, and damaged self. We also discuss the identification and structure–activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have signif..View full abstract
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We thank the Australian Research Council for financial support. Spencer J. Williams is an ARC funded Future Fellow.