Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

PG Hysi; CY Cheng; H Springelkamp; S Macgregor; JN Cooke Bailey; R Wojciechowski; V Vitart; A Nag; AW Hewitt; R Höhn; C Venturini; A Mirshahi; WD Ramdas; G Thorleifsson; E Vithana; CC Khor; AB Stefansson; J Liao; JL Haines; N Amin; YX Wang; PS Wild; AB Ozel; JZ Li; BW Fleck; T Zeller; SE Staffieri; YY Teo; G Cuellar-Partida; X Luo; RR Allingham; JE Richards; A Senft; LC Karssen; Y Zheng; C Bellenguez; L Xu; AI Iglesias; JF Wilson; JH Kang; EM Van Leeuwen; V Jonsson; U Thorsteinsdottir; DDG Despriet; S Ennis; SE Moroi; NG Martin; NM Jansonius; S Yazar; ES Tai; P Amouyel; J Kirwan; LME Van Koolwijk; MA Hauser; F Jonasson; P Leo; SJ Loomis; R Fogarty; F Rivadeneira; L Kearns; KJ Lackner; PTVM De Jong; CL Simpson; CE Pennell; BA Oostra; AG Uitterlinden; SM Saw; AJ Lotery; JE Bailey-Wilson; A Hofman; JR Vingerling; C Maubaret; N Pfeiffer; RCW Wolfs; HG Lemij; TL Young; LR Pasquale; C Delcourt; TD Spector; CCW Klaver; KS Small; KP Burdon; K Stefansson; TY Wong; AC Viswanathan; DA Mackey; JE Craig; JL Wiggs; CM Van Duijn; CJ Hammond; T Aung; JJ Wang; E Rochtchina; J Attia; R Scott; EG Holliday; PN Baird; J Xie; M Inouye; X Sim

Journal article

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

PG Hysi, CY Cheng, H Springelkamp, S Macgregor, JN Cooke Bailey, R Wojciechowski, V Vitart, A Nag, AW Hewitt, R Höhn, C Venturini, A Mirshahi, WD Ramdas, G Thorleifsson, E Vithana, CC Khor, AB Stefansson, J Liao, JL Haines, N Amin Show all

Nature Genetics | Published : 2014

DOI: 10.1038/ng.3087

Abstract

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10 '8 for rs6445055), two on chromosome 9 (P = 2.80 × 10 '11 for rs2472493 near ABCA1 and P = 6.39 × 10 '11 for rs8176693 wit..

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