Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysis
Julia C Cutts, Rosanna Powell, Paul A Agius, James G Beeson, Julie A Simpson, Freya JI Fowkes
BMC Medicine | BMC | Published : 2014
BACKGROUND: Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identified by seroepidemiological studies of individuals living in P. vivax-endemic areas, and is an important strategy given the limited ability to culture P. vivax in vitro. There have been numerous studies investigating the association between P. vivax antibody responses and P. vivax infection, but there has been no standardization of results to enable comparisons across populations. METHODS: We performed a systematic review with meta-analysis of popu..View full abstract
This work was supported by the National Health and Medical Research Council of Australia (project grant, fellowships to FJIF and JGB, and an Infrastructure for Research Institutes Support Scheme Grant), the Australian Research Council (Future Fellowship to FJIF and JGB), and a Victorian State Government Operational Infrastructure Support grant. The funders had no role in study design, data collection or analysis, decision to publish, or preparation of the manuscript.