Journal article

Influence of BDNF Val66Met on the relationship between physical activity and brain volume

Belinda M Brown, Pierrick Bourgeat, Jeremiah J Peiffer, Samantha Burnham, Simon M Laws, Stephanie R Rainey-Smith, David Bartres-Faz, Victor L Villemagne, Kevin Taddei, Alan Rembach, Ashley Bush, Kathryn A Ellis, S Lance Macaulay, Christopher C Rowe, David Ames, Colin L Masters, Paul Maruff, Ralph N Martins



OBJECTIVE: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations. RESULTS: The BDNF Val66Met polymorphism i..

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Funding Acknowledgements

B.B. was supported by a University Postgraduate Award from the University of Western Australia and a Freemasons' Western Australia Student Award. Core funding for this study was provided by CSIRO, which was supplemented by in-kind contributions from study partners. This research is supported by the Science and Industry Endowment Fund. The study also received support from the National Health and Medical Research Council via the Dementia Collaborative Research Centres program. Pfizer International has contributed financial support to assist with analysis of blood samples and to further the AIBL research program. The McCusker Alzheimer's Research Foundation Inc. contributed financial and in-kind support to AIBL. The authors acknowledge the financial support of the Cooperative Research Centre for Mental Health, from the Australian Government.