Journal article

Family History of Colorectal Cancer Is Not Associated with Colorectal Cancer Survival Regardless of Microsatellite Instability Status

Amanda I Phipps, Dennis J Ahnen, Peter T Campbell, Aung Ko Win, Mark A Jenkins, Noralane M Lindor, Robert Gryfe, John D Potter, Polly A Newcomb

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2014

Abstract

BACKGROUND: Individuals with a family history of colorectal cancer in first-degree relatives have an elevated risk of developing colorectal cancer themselves, particularly colorectal cancer exhibiting high microsatellite instability (MSI-high). Given that MSI-high colorectal cancer is associated with a favorable prognosis, it is plausible that having a family history of colorectal cancer could, in turn, be favorably associated with colorectal cancer survival. METHODS: This study comprised N = 4,284 incident colorectal cancer cases enrolled in the Colon Cancer Family Registry via population-based cancer registries. Using Cox proportional hazards regression, we evaluated the association betwee..

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Grants

Awarded by National Cancer Institute, NIH


Awarded by National Cancer Institute


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by grant UM1 CA167551 from the National Cancer Institute, NIH, and through cooperative agreements with members of the CCFR and Principal Investigators. Collaborating centers include Australasian Colorectal Cancer Family Registry, Mayo Clinic Cooperative Family Registry for Colon Cancer Studies, Ontario Registry for Studies of Familial Colorectal Cancer, and Seattle Colorectal Cancer Family Registry. This work was also supported by National Cancer Institute grants K07CA172298 and K05CA152715.