Journal article
Follow-up of blood-pressure lowering and glucose control in type 2 diabetes
S Zoungas, J Chalmers, B Neal, L Billot, Q Li, M Biostat, Y Hirakawa, H Arima, H Monaghan, R Joshi, S Colagiuri, ME Cooper, P Glasziou, D Grobbee, P Hamet, S Harrap, S Heller, L Lisheng, G Mancia, M Marre Show all
New England Journal of Medicine | Published : 2014
Abstract
Background In the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) factorial trial, the combination of perindopril and indapamide reduced mortality among patients with type 2 diabetes, but intensive glucose control, targeting a glycated hemoglobin level of less than 6.5%, did not. We now report results of the 6-year post-trial follow-up.Methods We invited surviving participants, who had previously been assigned to perindopril- indapamide or placebo and to intensive or standard glucose control (with the glucose-control comparison extending for an additional 6 months), to participate in a post-trial follow-up evaluation. The prima..
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Awarded by Medical Research Council
Funding Acknowledgements
Funded by the National Health and Medical Research Council of Australia and others; ADVANCE-ON ClinicalTrials.gov number, NCT00949286.)