Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region

CF Skibola; SI Berndt; J Vijai; L Conde; Z Wang; M Yeager; PIW De Bakker; BM Birmann; CM Vajdic; JN Foo; PM Bracci; RCH Vermeulen; SL Slager; S De Sanjose; SS Wang; MS Linet; G Salles; Q Lan; G Severi; H Hjalgrim; T Lightfoot; M Melbye; J Gu; H Ghesquières; BK Link; LM Morton; EA Holly; A Smith; LF Tinker; LR Teras; A Kricker; N Becker; MP Purdue; JJ Spinelli; Y Zhang; GG Giles; P Vineis; A Monnereau; KA Bertrand; D Albanes; A Zeleniuch-Jacquotte; A Gabbas; CC Chung; L Burdett; A Hutchinson; C Lawrence; R Montalvan; L Liang; J Huang; B Ma; J Liu; HO Adami; B Glimelius; Y Ye; GS Nowakowski; A Dogan; CA Thompson; TM Habermann; AJ Novak; M Liebow; TE Witzig; GJ Weiner; M Schenk; P Hartge; AJ De Roos; W Cozen; D Zhi; NK Akers; J Riby; MT Smith; M Lacher; DJ Villano; A Maria; E Roman; E Kane; RD Jackson; KE North; WR Diver; J Turner; BK Armstrong; Y Benavente; P Boffetta; P Brennan; L Foretova; M Maynadie; A Staines; J McKay; AR Brooks-Wilson; T Zheng; TR Holford; S Chamosa; R Kaaks; RS Kelly; B Ohlsson; RC Travis; E Weiderpass; J Clavel; E Giovannucci; P Kraft; J Virtamo

Journal article

Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region

CF Skibola, SI Berndt, J Vijai, L Conde, Z Wang, M Yeager, PIW De Bakker, BM Birmann, CM Vajdic, JN Foo, PM Bracci, RCH Vermeulen, SL Slager, S De Sanjose, SS Wang, MS Linet, G Salles, Q Lan, G Severi, H Hjalgrim Show all

American Journal of Human Genetics | Published : 2014

DOI: 10.1016/j.ajhg.2014.09.004

Abstract

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10 -20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10 -11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10 -10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10 -10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10 -8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at po..

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University of Melbourne Researchers

Graham Giles Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

The overall FL GWAS project was supported by the intramural program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH. A full list of Supplemental Acknowledgements is provided online.