Journal article

An objective measure of growth rate using partial biopsy specimens of melanomas that were initially misdiagnosed

Matthew J Lin, Victoria Mar, Catriona McLean, John W Kelly

Journal of the American Academy of Dermatology | MOSBY-ELSEVIER | Published : 2014

Abstract

BACKGROUND: To calculate melanoma rate of growth (ROG), previous studies have relied on subjective patient recall to estimate time delay to diagnosis. OBJECTIVE: To objectively calculate ROG by measuring the rate of increase in melanoma thickness between 2 sequential biopsy specimens over time. METHODS: This was a retrospective review of 51 melanomas in which pathologic misdiagnosis of a partial biopsy specimen caused a delay before referral and excisional biopsy between January 1998 and January 2013. ROG was calculated as rate of increase in tumor thickness between biopsy specimens. RESULTS: The median delay between the 2 biopsy specimens was 27 months (range, 3-89 months). Biopsy specimens..

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