Journal article
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
Graham A Heap, Michael N Weedon, Claire M Bewshea, Abhey Singh, Mian Chen, Jack B Satchwel, Julian P Vivian, Kenji So, Patrick C Dubois, Jane M Andrews, Vito Annese, Peter Bampton, Martin Barnardo, Sally Bell, Andy Cole, Susan J Connor, Tom Creed, Fraser R Cummings, Mauro D'Amato, Tawfique K Daneshmend Show all
Nature Genetics | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/ng.3093
Grants
Awarded by Wellcome Trust Institutional Strategic Support Award
Awarded by Academy of Medical Sciences (AMS)
Awarded by Medical Research Council
Awarded by National Institute for Health Research
Awarded by Crohn"s and Colitis UK
Awarded by Chief Scientist Office
Funding Acknowledgements
The International Serious Adverse Events Consortium (iSAEC) funded the sample collection and genotyping. The UK National Institute for Health Research (NIHR) provided research nurse support to facilitate recruitment at all UK research sites. We thank Crohn's and Colitis UK for funding support and publicizing this study to its members. A Wellcome Trust Institutional Strategic Support Award (WT097835MF) generously supported the work in this study. Genotyping was undertaken at the Broad Institute, Cambridge, Massachusetts, USA. We thank all the clinicians who assisted with sample collection as part of the IBD Pharmacogenetics Study Group (listed in the Supplementary Note) and the International IBD Genetics Consortium, as well as S. Marriott for her assistance during the trial initiation. We acknowledge The International Serious Adverse Events Scientific Management Committee members (listed in the Supplementary Note), T Frayling, S. Lin and K. Hunt for kindly providing comments on the draft manuscript, as well as C. Heard and M. Parkinson for their ongoing administrative support to the study. We also thank all the patients for their time and participation.