Journal article
Marker genes identify three somatic cell types in the fetal mouse ovary
RH Rastetter, P Bernard, JS Palmer, AA Chassot, H Chen, PS Western, RG Ramsay, MC Chaboissier, D Wilhelm
Developmental Biology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
Abstract
The two main functions of the ovary are the production of oocytes, which allows the continuation of the species, and secretion of female sex hormones, which control many aspects of female development and physiology. Normal development of the ovaries during embryogenesis is critical for their function and the health of the individual in later life. Although the adult ovary has been investigated in great detail, we are only starting to understand the cellular and molecular biology of early ovarian development. Here we show that the adult stem cell marker Lgr5 is expressed in the cortical region of the fetal ovary and this expression is mutually exclusive to FOXL2. Strikingly, a third somatic c..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
We thank Dr Andrew Pask for critical reading of the manuscript. The authors acknowledge the facilities, scientific and technical assistance of Monash Micro Imaging, Monash University, Victoria, Australia and the Australian Cancer Research Foundation Dynamic Imaging Centre for Cancer Biology, University of Queensland, Brisbane, Australia. This work was supported by research grants from the National Health and Medical Research Council of Australia (NHMRC grant number 631460 and a Fellowship to RGR), the Fondation ARC pour la Recherche sur le Cancer PJA 20131200236, and the Victorian Government's Operational Infrastructure Support Program. DW is a Future Fellow of the ARC (FT110100327).