Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion
Hilary A Kenny, Chun-Yi Chiang, Erin A White, Elizabeth M Schryver, Mohammed Habis, Iris L Romero, Andras Ladanyi, Carla V Penicka, Joshy George, Karl Matlin, Anthony Montag, Kristen Wroblewski, S Diane Yamada, Andrew P Mazar, David Bowtell, Ernst Lengyel
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2014
Awarded by NCI
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
Awarded by NATIONAL CANCER INSTITUTE
We thank A.F. Haney (Department of Obstetrics and Gynecology, University of Chicago) for collecting omental biopsies, G. Isenberg (University of Chicago) for editing the manuscript, A. Mitra for helpful discussions, R. Fassler and S. Dallas for the Fn1<SUP>fl/fl</SUP> mice, S. Carbonell and OncoSynergy for providing the beta<INF>1</INF>, integrin antibody, K. Roby for providing the ID8 cell line, G.B. Mills for providing the HeyA8 and SKOV3ip1 cell lines, and the human tissue resource center (Terri Li and Lei-Ann Arceneaux) and flow cytometry (Ryan Duggan) core facilities at the University of Chicago for expert technical support. This work was supported by NCI grant R01 CA111882 and by an Ovarian Cancer Research Fund Program Project Development Grant to E. Lengyel. Finally, we appreciate all the patients, resident physicians, and attending physicians in the Department of Obstetrics and Gynecology at the University of Chicago for their commitment in collecting tissue.