Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
Jason M Brouwer, Dana Westphal, Grant Dewson, Adeline Y Robin, Rachel T Uren, Ray Bartolo, Geoff V Thompson, Peter M Colman, Ruth M Kluck, Peter E Czabotar
Molecular Cell | CELL PRESS | Published : 2014
Awarded by NHMRC (Australia)
We thank Ahmad Wardak and Callum Lawrence for technical support, beamline staff at the Australian Synchrotron where diffraction data were collected, and Masato Kawasaki for the pET28a-GFP vector. Crystallization experiments were performed at the Bio21 C3 Collaborative Crystallization Centre. P. E. C., G. D., and R. M. K. acknowledge ARC Future Fellowships; J.M.B. acknowledges an Australian Postgraduate Award; and P. M. C. acknowledges an NHMRC Fellowship. Our work is supported by NHMRC (Australia; Projects Grants 1059331 and 1023055 and Program Grant 1016701), the Australian Cancer Research Foundation, the Leukemia and Lymphoma Society (US), the Victorian State Government Operational Infrastructure Support, and the Australian Government NHMRC IRIISS.