Journal article
Nfil3 is required for the development of all innate lymphoid cell subsets
C Seillet, LC Rankin, JR Groom, LA Mielke, J Tellier, M Chopin, ND Huntington, GT Belz, S Carotta
Journal of Experimental Medicine | Published : 2014
DOI: 10.1084/jem.20140145
Abstract
Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate lymphoid lineages. Here, we identify that Nfil3 is essential for the development of Peyer's patches and ILC2 and ILC3 subsets. Loss of Nfil3 selectively reduced Peyer's patch formation and was accompanied by impaired recruitment and distribution of lymphocytes within the patches. ILC subsets exhibited high Nfil3 expression and genetic deletion of Nfil3 severely compromised the development of all subsets..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
L.C. Rankin was supported by a National Health and Medical Research Council (NHMRC; Australia) Dora Lush Training Scholarship; J.R. Groom was supported by an NHMRC Overseas Postgraduate Training Fellowship; L.A. Mielke was supported by a Cancer Australia grant (APP1050241); G.T. Belz was supported by an Australian Research Council Future Fellowship; and S. Carotta was supported by an NHMRC Career Development Fellowship (APP1011808). This work was supported by NHMRC project grants (APP1027472 and APP1047903) of the NHMRC of Australia, Victorian State Government Operational Infrastructure Support, and Australian Government NHMRC IRIIS.