Journal article
Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland
J Sanderson, DA Dartt, V Trinkaus-Randall, J Pintor, MM Civan, NA Delamere, EL Fletcher, TE Salt, A Grosche, CH Mitchell
Experimental Eye Research | Published : 2014
Abstract
This review highlights recent findings that describ how purines modulate the physiological and pathophysiological responses of ocular tissues. For example, in lacrimal glands the cross-talk between P2X7 receptors and both M3 muscarinic receptors and α1D-adrenergic receptors can influence tear secretion. In the cornea, purines lead to post-translational modification of EGFR and structural proteins that participate in wound repair in the epithelium and influence the expression of matrix proteins in the stroma. Purines act at receptors on both the trabecular meshwork and ciliary epithelium to modulate intraocular pressure (IOP); ATP-release pathways of inflow and outflow cells differ, possibly ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by grants from the National Institute of Health EY013434 (CHM) EY015537 (CHM) EY009532 (NAD) EY06915 (NAD) EY013624 (MMC) EY01583 (MMC & CHM) EY006177 (DAD) EY06000 (VTR), EY06000S (VTR), New England Corneal Transplant Fund (VTR) Ophthalmology Departmental grant from Massachusetts Lions Eye Research Fund, Inc (VTR), The Humane Research Trust (JS), The Norwich Glaucoma Research Fund (JS), Universidad Complutense de Madrid Project GR35/10-A-920777 (JP), the Ministry of Economy SAF 2010/16024 (JP), Institute Carlos III Redes tematicas de investigacion cooperativa en salud RD12/0034/0003 (JP), the Jody Sack Fund (CHM), the DFG GR4403/1-1 (AG), FOR 748 (AG), PRO RETINA Deutschland e. V. (AG). The authors would like to acknowledge contributions of J Banerjee, S Chavda, CT Leung, M Leonard, A Li, KL Li, W Lu, PJ Luthert, M Shahidullah and WD Stamen CHM has IP that relates to some of the topics discussed above.