Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke
Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014
Awarded by National Health and Medical Research Council (NHMRC) Grants
Awarded by NHMRC Independent Research Institute Infrastructure Support Grant
We thank staff in the Walter and Eliza Hall Institute Bioservices Facility; Drs. Robert Ninnis, Grant Dewson, and James Vince for advice; Vishva Dixit for Ripk3<SUP>-/-</SUP> mice; and Toru Okamoto for developing inducible lentiviral vectors. This work was supported by National Health and Medical Research Council (NHMRC) Grants 1057905, 1067289, 1046984, 1025594, and 461221 and fellowships (to J.M.H., W.S.A., and J.S.); a Victorian International Research Scholarship (to M.C.T.); a C. R. Roper Fellowship (to R.C.J.D.); and Australian Research Council fellowships (to J.J.B., P.E.C., and J.M.M.). Additional support was obtained from the Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support, and NHMRC Independent Research Institute Infrastructure Support Grant 361646.