Journal article
The neural crest: A versatile organ system
D Zhang, S Ighaniyan, L Stathopoulos, B Rollo, K Landman, J Hutson, D Newgreen
Birth Defects Research Part C Embryo Today Reviews | Published : 2014
DOI: 10.1002/bdrc.21081
Abstract
The neural crest is the name given to the strip of cells at the junction between neural and epidermal ectoderm in neurula-stage vertebrate embryos, which is later brought to the dorsal neural tube as the neural folds elevate. The neural crest is a heterogeneous and multipotent progenitor cell population whose cells undergo EMT then extensively and accurately migrate throughout the embryo. Neural crest cells contribute to nearly every organ system in the body, with derivatives of neuronal, glial, neuroendocrine, pigment, and also mesodermal lineages. This breadth of developmental capacity has led to the neural crest being termed the fourth germ layer. The neural crest has occupied a prominent..
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Funding Acknowledgements
D.Z, S. I, L. S., and B. R. contributed equally to this review. The authors apologize to all authors whose contributions to NC research could not be included due to spatial constraints. The authors have no conflict of interest to declare. This review was assembled under NHMRC grants 607379, 1069757, and 1050692. We acknowledge MCRI Theme grant support and the Victorian Government's Operational Infrastructure Support Program to MCRI. L. S. was sponsored by Fonds du Service de Chirurgie Pediatrique et de Perfectionnement du CHUV, the SICPA Fundation, and the Societe Academique Vaudoise, Lausanne, Switzerland.