Journal article

The Effect of Acute Exercise on Undercarboxylated Osteocalcin and Insulin Sensitivity in Obese Men

Itamar Levinger, George Jerums, Nigel K Stepto, Lewan Parker, Fabio R Serpiello, Glenn K McConell, Mitchell Anderson, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2014

Abstract

Acute exercise improves insulin sensitivity for hours after the exercise is ceased. The skeleton contributes to glucose metabolism and insulin sensitivity via osteocalcin (OC) in its undercarboxylated (ucOC) form in mice. We tested the hypothesis that insulin sensitivity over the hours after exercise is associated with circulating levels of ucOC. Eleven middle-aged (58.1 ± 2.2 years mean ± SEM), obese (body mass index [BMI] = 33.1 ± 1.4 kg/m(2) ) nondiabetic men completed a euglycemic-hyperinsulinemic clamp at rest (rest-control) and at 60 minutes after exercise (4 × 4 minutes of cycling at 95% of HRpeak ). Insulin sensitivity was determined by glucose infusion rate relative to body mass (GI..

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Grants

Awarded by National Heart Foundation of Australia


Funding Acknowledgements

IL was supported by Future Leader Fellowship (ID: 100040) from the National Heart Foundation of Australia, and this article represents a collaboration between The University of Melbourne and Victoria University as part of the Collaborative Research Network (CRN) programme. The study was funded by a Victoria University grant.