Journal article

A Novel Combination of Homeobox Genes Is Expressed in Mesenchymal Chorionic Stem/Stromal Cells in First Trimester and Term Pregnancies

Haiying Liu, Padma Murthi, Sharon Qin, Gina D Kusuma, Anthony J Borg, Martin Knoefler, Peter Haslinger, Ursula Manuelpillai, Mark D Pertile, Mohamed Abumaree, Bill Kalionis



Human chorionic mesenchymal stem/stromal cells (CMSCs) derived from the placenta are similar to adult tissue-derived MSCs. The aim of this study was to investigate the role of these cells in normal placental development. Transcription factors, particularly members of the homeobox gene family, play crucial roles in maintaining stem cell proliferation and lineage specification in embryonic tissues. In adult tissues and organs, stem cells proliferate at low levels in their niche until they receive cues from the microenvironment to differentiate. The homeobox genes that are expressed in the CMSC niche in placental tissues have not been identified. We used the novel strategy of laser capture micr..

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Awarded by KAIMRC

Awarded by KACST

Awarded by NHMRC

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: We acknowledge the financial support of KAIMRC Grant No. RC08/114, KACST Grant No. ARP-29-186, and NHMRC Grant No. 509178.