Journal article
Amyloid-β related memory decline is not associated with subjective or informant rated cognitive impairment in healthy adults
S Hollands, YY Lim, R Buckley, RH Pietrzak, PJ Snyder, D Ames, KA Ellis, K Harrington, N Lautenschlager, RN Martins, CL Masters, VL Villemagne, CC Rowe, P Maruff
Journal of Alzheimer S Disease | Published : 2015
DOI: 10.3233/JAD-140678
Abstract
Background: The detection of early Alzheimer's disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear. Objective: To determine the extent to which impairment or decline in subjective and informant rated cognitive impairment was associated with memory in healthy older adults with high Aβ. Methods: Healthy older adults (n = 289) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were studied at baseline. Pittsburgh Compound B was used to determine Aβ status at baseline. At baseline and 18 months ..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, Cogstate Ltd.]. The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre for Mental Health (CRCMH).