Journal article
Diffuse ventricular fibrosis measured by T1 mapping on cardiac MRI predicts success of catheter ablation for atrial fibrillation
AJA McLellan, LH Ling, S Azzopardi, AH Ellims, LM Iles, MA Sellenger, JB Morton, JM Kalman, AJ Taylor, PM Kistler
Circulation Arrhythmia and Electrophysiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
Background-There is a complex interplay between the atria and ventricles in atrial fibrillation (AF). Cardiac magnetic esonance (CMR) imaging provides detailed tissue characterization, identifying focal ventricular fibrosis with late gadolinium enhancement (ventricular late gadolinium enhancement) and diffuse fibrosis with postcontrast-enhanced T1 mapping. The aim of the present study was to investigate the relationship between postcontrast ventricular T1 relaxation time on CMR and freedom from AF after pulmonary vein isolation. Methods and Results-One hundred three patients undergoing catheter ablation for symptomatic AF (66% paroxysmal AF; age,58±10 years; left atrial area, 27±7 cm2) under..
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Funding Acknowledgements
Drs McLellan and Ellims are both supported by a co-funded Australian National Health and Medical Research Council (NHMRC) and Australian National Heart Foundation (NHF) Postgraduate Scholarship and Baker IDI Bright Sparks Scholarship. Dr Ling is supported by an Australian National Heart Foundation Postgraduate Scholarship. Dr Iles is supported by an NHMRC postgraduate research scholarship. A/Professor Taylor is supported by an NHMRC project grant. A/Professor Kistler is supported by a practitioner fellowship from the NHMRC. All other authors have reported that they have no financial relationships to disclose. This research is supported, in part, by the Victorian Government's Operational Infrastructure Funding.