Journal article

Energy-based analysis of biochemical cycles using bond graphs

Peter J Gawthrop, Edmund J Crampin

Proceedings of the Royal Society A: Mathematical, Physical & Engineering Sciences | ROYAL SOC | Published : 2014

Abstract

Thermodynamic aspects of chemical reactions have a long history in the physical chemistry literature. In particular, biochemical cycles require a source of energy to function. However, although fundamental, the role of chemical potential and Gibb's free energy in the analysis of biochemical systems is often overlooked leading to models which are physically impossible. The bond graph approach was developed for modelling engineering systems, where energy generation, storage and transmission are fundamental. The method focuses on how power flows between components and how energy is stored, transmitted or dissipated within components. Based on the early ideas of network thermodynamics, we have a..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Virtual Physiological Rat Centre for the Study of Physiology and Genomics - NIH


Funding Acknowledgements

This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project no. CE140100036), and by the Virtual Physiological Rat Centre for the Study of Physiology and Genomics, funded through NIH grant P50-GM094503. P.J.G. thanks the Melbourne School of Engineering for its support via a Professorial Fellowship.