Journal article

Comparison of MR-less PiB SUVR quantification methods

Pierrick Bourgeat, Victor L Villemagne, Vincent Dore, Belinda Brown, S Lance Macaulay, Ralph Martins, Colin L Masters, David Ames, Kathryn Ellis, Christopher C Rowe, Olivier Salvado, Jurgen Fripp



(11)C-Pittsburgh compound B (PiB) is a positron emission tomography (PET) tracer designed to bind to amyloid-β (Aβ) plaques, one of the hallmarks of Alzheimer's disease (AD). The potential of PiB as an early marker of AD led to the increasing use of PiB in clinical research studies and development of several F-18-labeled Aβ radiotracers. Automatic quantification of PiB images requires an accurate parcellation of the brain's gray matter (GM). Typically, this relies on a coregistered magnetic resonance imaging (MRI) to extract the cerebellar GM, compute the standardized uptake value ratio (SUVR), and provide parcellation and segmentation for quantification of regional and global SUVR. However,..

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Funding Acknowledgements

Australian Imaging, Biomarkers, and Lifestyle is a large collaborative study, and a complete list of contributors can be found at our Web site We thank all who took part in the study. This research is supported by the Science and Industry Endowment Fund ( Approval for the study was obtained from the Austin Health Human Research Ethics Committee. Written informed consent for participation was obtained for all patients before the scans.