Journal article

Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications

BS Fernandes, J Steiner, M Berk, ML Molendijk, A Gonzalez-Pinto, CW Turck, P Nardin, C-A Goncalves

Molecular Psychiatry | NATURE PUBLISHING GROUP | Published : 2015

Abstract

It has been postulated that schizophrenia (SZ) is related to a lower expression of brain-derived neurotrophic factor (BDNF). In the past few years, an increasing number of divergent clinical studies assessing BDNF in serum and plasma have been published. It is now possible to verify the relationship between BDNF levels and severity of symptoms in SZ as well as the effects of antipsychotic drugs on BDNF using meta-analysis. The aims of this study were to verify if peripheral BDNF is decreased in SZ, whether its levels are correlated with positive and negative symptomatology and if BDNF levels change after antipsychotic treatment. This report consists of two distinct meta-analyses of periphera..

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University of Melbourne Researchers

Grants

Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

We thank all the authors of the included papers, particularly Drs Katerina Antoniou, Ryota Hashimoto, Yong-Ku Kim, Emmanouil Rizos, Mina Rostami, Mehrdad Taghipour and Ganesan Venkatasubramanian, who very kindly provided us with unpublished data for our paper. BSF is supported by a scholarship from CAPES, Brazil. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660.