Journal article

Weight and fat distribution in patients taking valproate: A valproate-discordant gender-matched twin and sibling pair study

Sandra J Petty, Susan Kantor, Kate M Lawrence, Samuel F Berkovic, Marnie Collins, Keith D Hill, Joanna Makovey, Philip N Sambrook, Terence J O'Brien, John D Wark

EPILEPSIA | WILEY | Published : 2014

Abstract

OBJECTIVES: Chronic treatment with valproate (VPA) is commonly associated with weight gain, which potentially has important health implications, in particular increased central fat distribution. We utilized a VPA-discordant same-sex, twin and matched sibling pair study design to primarily examine for differences in fat distribution between patients with epilepsy treated with VPA compared to their matched twin or sibling control. Weight, blood pressure, and leptin levels were assessed. METHODS: Height, weight, waist and hip measurements, exercise, blood pressure (BP), and serum leptin levels were measured. Body composition was measured using dual-energy x-ray absorptiometry (DXA). Abdominal f..

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Grants

Awarded by National Health & Medical Research Council (NHMRC)


Awarded by NHMRC project grant


Awarded by MBC Postdoctoral Medical Research Fellowship at The Melbourne Brain Centre RMH (NHMRC Centre for Research Excellence Grant)


Funding Acknowledgements

This research was facilitated through access to the Australian Twin Registry, a national resource supported by an Enabling Grant (ID 628911) from the National Health & Medical Research Council (NHMRC). The Bone Research Program in Twins (University of Melbourne) was funded by the NHMRC. The study was partially funded by an NHMRC project grant (ID 400089). Dr. Sandra Petty was supported by NHMRC Postgraduate Scholarship during this project, and is currently supported by an MBC Postdoctoral Medical Research Fellowship at The Melbourne Brain Centre RMH (NHMRC Centre for Research Excellence Grant 1001216).