Journal article
Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression
OM Dean, A Turner, GS Malhi, C Ng, SM Cotton, S Dodd, J Sarris, Y Samuni, M Tanious, N Dowling, A Waterdrinker, D Smith, M Berk
Revista Brasileira De Psiquiatria | Published : 2015
Abstract
Objective: Bipolar disorder places a significant burden on individuals, caregivers and family, and the broader community. Current treatments are believed to be more effective against manic symptoms, leaving a shortfall in recovery during the depressive phase of the illness. The current study draws on recent evidence suggesting that, in addition to increased oxidative load, alterations in mitochondrial function occur in bipolar disorder. Methods: This 16-week study aims to explore the potential benefits of N-acetylcysteine (NAC) alone or in combination (CT) with selected nutraceuticals believed to enhance mitochondrial function. The study includes adults diagnosed with bipolar disorder curren..
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Funding Acknowledgements
The authors would like to acknowledge the support of the National Health and Medical Research Council (NHMRC) and The Cooperative Research Centre for Mental Health. We would also like to acknowledge the service support of Barwon Health, Deakin University, The Melbourne Clinic, University of Melbourne, University of Sydney, and the Royal North Shore Hospital. The trial agents were donated by Bioceuticals and supplied by Catalent and Nutrition Care. OMD has received grant support from the Brain and Behavior Foundation, Simons Autism Foundation, Stanley Medical Research Institute, and the National Health and Medical Research Council (NHMRC). SD has received research support from the Stanley Medical Research Institute, NHMRC, Beyond Blue, ARHRF, Simons Foundation, and Geelong Medical Research Foundation. JS is sponsored by a CR Roper Fellowship and has received grant support from NHMRC. MB has received grant support from the National Institutes of Health (NIH), Simons Autism Foundation, Cancer Council of Victoria, CRC for Mental Health, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, and Geelong Medical Research Foundation.